Advances in Chromatography: Volume 48
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Urine A recent study showed that well-trained dogs can detect the presence of cancer in a cancer patient's urine samples based on urine odour Figure 4. Extracellular fluid The extracellular compartment EC contains low molecular metabolites as well as proteins and peptides in the extracellular fluid ECF. The scope and outlook - the future of gas chromatographic methods in oncology The use of GC methods for the detection, diagnosis, and to monitor treatment of cancer have over the past decade become more common through the use of a variety of sample matrices, as described above mainly exhaled air, tissue, blood and urine but also extracellular fluid.
Biographies Dr. References 1. Chemical carcinogenesis. An Acad Bras Cienc.
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Cancer statistics, CA Cancer J Clin. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation.
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Mantovani A. Cancer: inflaming metastasis. Sugar and fat - that's where it's at: metabolic changes in tumors. Breast Cancer Res. Cuperlovic-Culf M. Wang, E, editor. Cancer Metabolic Networks. The case for early detection. Nat Rev Cancer. Fluorescein electronic endoscopy: a novel method for detection of early stage gastric cancer not evident to routine endoscopy. Spreading evaluation in primitive bronchogenic carcinoma: benefit of cerebral MRI compared to CT scan.
Eur J Cancer. Kopans DB. Lancet ; Serkova NJ, Glunde K. Metabolomics of cancer. Methods Mol Biol. Metabolomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis. Clin Chim Acta. Magnetic resonance spectroscopy.
J Neuroophthalmol. Mass spectrometry based metabolomic approaches in urinary biomarker study of women's cancers. Prediction of lung cancer using volatile biomarkers in breath. Cancer Biomarkers.
Detection of lung cancer using weighted digital analysis of breath biomarkers. Detection of lung cancer with volatile markers in the breath. Volatile biomarkers of pulmonary tuberculosis in the breath. Effect of age on the breath methylated alkane contour, a display of apparent new markers of oxidative stress.
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Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study. Prediction of breast cancer using volatile biomarkers in the breath. Breast Cancer Res Treat. Prediction of heart transplant rejection with a breath test for markers of oxidative stress.
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Am J Cardiol. Effect of oxygen on breath markers of oxidative stress. Eur Respir J. Fiehn O. Metabolomics - the link between genotypes and phenotypes. Potsdam: Kluwer Academic Publishers; Biomarkers definitions working group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. Recent advances in biomarkers for cancer diagnosis and treatment. Drug Discov Today. Gillatt D, Reynard JM. What is the 'normal range' for prostate-specific antigen?
Use of a receiver operating characteristic curve to evaluate a serum marker. Br J Urol.
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William P, Juliann C. J Biomed Biotechnol. Horn L, Pao W. J Clin Oncol. Clinical significance of BRAF gene mutations in patients with non-small cell lung cancer. Anticancer Res. Phases of biomarker development for early detection of cancer. J Natl Cancer Inst. Diamandis EP. Simon R. Roadmap for developing and validating therapeutically relevant genomic classifiers. Warburg O. The Metabolism of Tumors. London: Constable; Pasteur L.
Experiences et vues nouvelles sur la nature des fermentations. Comp Rend Acad Sci. The bioenergetic signature of cancer: a marker in tumor progression. Cancer Res. Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell.
Eigenbrodt E, Glossmann H. Glycolysis - one of the keys to cancer? Trends Pharmacol Sci.
Kroemer G, Pouyssegur J. Reinacher M, Eigenbrodt E. Immunohistological demonstration of the same type of pyruvate kinase isoenzyme M2-PK in tumors of chicken and rat. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol. Colorectal cancer screening by non-invasive metabolic biomarker fecal tumor. World J Gastroenterol. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of c-myc activity.
Hypoxia-inducible factor 1 HIF-1 in cancer. Eur J Surg Oncol. Akt stimulates aerobic glycolysis in cancer cells. Surfing the p53 network. AMP-activated protein kinase induces a pdependent metabolic checkpoint. Mol Cell. Oncogenic alterations of metabolism. Trends Biochem Sci. Exhaled breath analysis: Novel approach for early detection of lung cancer.